Coronavirus pandemic (COVID-19), McMahon D.E., Amerson E., Rosenbach M., et al. You cant spread pityriasis rosea to another person through unprotected sex or skin-to-skin contact. FOIA The https:// ensures that you are connecting to the JAAD Case Rep. 2021;7:9394. sharing sensitive information, make sure youre on a federal Would you like email updates of new search results? Get more info about other skin conditions: The Ultimate Guide to Skin Conditions for Black & Brown Folks, I Thought I Just Had Dry Skin, But It Was Actually Perioral Dermatitis, Everything You Should Know About Hidradenitis Suppurativa. Anyone can get pityriasis rosea. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Front Med (Lausanne). Fried foods, including many fast-food items. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Epub 2020 Jun 29. Epub 2022 Feb 9. doi: 10.1111/bjd.20143. COVID-19; HHV, human herpes virus; Moderna; PR; PR, pityriasis rosea; PR-LE; PR-LE, pityriasis rosea-like eruption; Pfizer; coronavirus; dermatology; mRNA vaccine; mRNA, messenger RNA; pityriasis rosea; pityriasis rosealike eruption; vaccine. 2023 Cond Nast. PS conceptualized the case report and revised the manuscript. HHS Vulnerability Disclosure, Help Rationale: Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same vaccine. -, Drago F, Ciccarese G, Javor S, Parodi A. Vaccineinduced pityriasis rosea and pityriasis rosealike eruptions: a review of the literature. Bethesda, MD 20894, Web Policies Epub 2022 Jan 31. Atzori L, Pinna AL, Ferreli C, Aste N. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center. It said blood spots under the skin might also be present, either as spots or dots or on larger areas. The most commonly reported features . The cause of pityriasis rosea is not known, but it is commonly believed to be caused by a virus or bacteria. The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations. PMC The clinics of HHV-6 infection in COVID-19 pandemic: Pityriasis rosea and Kawasaki disease. An official website of the United States government. doi: 10.1111/bjd.20143. In addition to COVID-19 vaccination, she was currently taking medications (i.e., levetiracetam and thyroxin) for glioblastoma, and the two drugs had been prescribed for approximately nine months. eCollection 2022. 9 , 10 These findings suggest that immuneinduced viral reactivation - rather than World J Clin Cases. F. Drago, G. Ciccarese, A. Parodi Suchonwanit P, Leerunyakul K, Kositkuljorn C. Cutaneous manifestations in COVID-19: Lessons learned from current evidence. government site. Cazzato G, Ambrogio F, Pisani MC, Colagrande A, Arezzo F, Cascardi E, Dellino M, Macorano E, Trilli I, Parente P, Lettini T, Romita P, Marzullo A, Ingravallo G, Foti C. Vaccines (Basel). 2021 Nov;35(11):e721-e722. Cutis. Disclaimer. I figured a very determined mosquito had snuck into my room and attacked me through my tank top. 2022 Mar 9;35(3):342-343. doi: 10.1080/08998280.2022.2044742. Is there a prescription cream or ointment that you can prescribe? Luckily, it's not contagious. doi: 10.1007/s10103-019-02783-8, 16. Herald patch of pityriasis rosea. A 52-year-old Thai woman with a one-year history of recurrent glioblastoma was admitted to our hospital for a planned targeted therapy. Pityriasis rosea often occurs this way, but not always. 1. 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity doi: 10.1159/000517971. Epub 2022 Jun 13. J Eur Acad Dermatol Venereol. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage lines, most appreciable on the upper portion of the chest. I video-chatted with my dermatologist who asked a few questions: Did I have body aches or flu-like symptoms? If you have a very itchy rash, your healthcare provider may prescribe the following to help relieve your symptoms: There are several over-the-counter products or home remedies that can help stop your rash from itching. This site needs JavaScript to work properly. You may be more likely to develop it if youre: In some cases, people with pityriasis rosea report that they had significant or long-term stress before developing a rash. Fortunately, PR-like eruption is responsive to topical corticosteroids without any systemic adverse effects. We present a case of a pityriasis rosea-like rash occurring after Pfizer COVID-19 vaccination and review cases of pityriasis rosea (PR)/PR-like eruption (PR-LE) after mRNA COVID-19 vaccine published in the medical literature. (2017) 5:20311. Human herpesvirus-6, -7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. Bookshelf (Within two days, and still no.) 2022 Mar 15;10(3):624. doi: 10.3390/microorganisms10030624. National Library of Medicine Before Keywords: Among patients who received COVID-19 vaccines, PR-like eruptions have been reported following the first (n = 1) or second dose (n = 2) of BNT162b2 mRNA-based vaccines (3, 4). Another skin condition identified in the study were "vesicular eruptions" seen in 9 per cent of cases. Treatment with topical 0.1% triamcinolone acetonide twice daily showed partial response after seven days. PMC Birlutiu V, Dobritoiu ES, Lupu CD, Herteliu C, Birlutiu RM, Dragomirescu D, Vorovenci A. official website and that any information you provide is encrypted This tiny glimpse of her natural texture is thrilling. Although the exact pathogenesis of PR remains unknown, the endogenous systemic reactivation of HHV (i.e., type 6 and 7) in the skin has been implicated as a precipitating factor. Please enable it to take advantage of the complete set of features! Shabazz DR. Pityriasis Rosea. MeSH 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. This Month in JAAD International: August 2022: Cutaneous reactions to COVID-19 messenger RNA booster dose vaccination. Yes, There Is a Correct Order for Everything You Do in the Shower, Each Zodiac Sign's Unique Personality Traits, Swoopy 1960s Hair Was Everywhere at the SAG Awards, Christina Aguilera Opened Up About Getting Injections and Why She Doesn't Care If People Judge Her, "I think we all can rely on a little help. 6 Called a "herald patch,". For instance, the rash sometimes appears only under the arms or on the flanks. Please enable it to take advantage of the complete set of features! Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. 2021;85(1):4655. Epub 2022 Jun 21. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. Studies show that some skin conditions may appear with COVID-19, including pityriasis rosea. 2020 Jul;33(4):e13730. 18. We evaluated the clinical and pathologic spectrum of mucocutaneous reactions following COVID-19 vaccines, observed consecutively within three large tertiary Centers of the Metropolitan City of Milan . J Med Virol 2021; 93: 18501851. Your healthcare provider can typically diagnose pityriasis rosea after a physical exam. Flares of other types of skin conditions [like psoriasis] sometimes have been described as well," says Lam. Women and young people are most likely to have these reactions. Unable to load your collection due to an error, Unable to load your delegates due to an error. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. However, after 14 days, she developed multiple discrete blanching erythematous oval patches and plaques on the lower abdomen, back, and bilateral upper thighs (Figures 1A,B). 2021 Sep;60(9):1150-1151.doi: 10.1111/ijd.15700. As King notes, there have been some reported cases of pityriasis rosea occurring in patients after receiving certain vaccines, like the flu shot. Moreover, almost all lesions faded with associated post-inflammatory hyperpigmentation (Figure 2B). The site is secure. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Sprinkle bath water with an oatmeal-based bath product (Aveeno). JAAD Case Rep 2018; 4: 800801. It looked like one, and it certainly itched like one but then more came. Clin Dermatol. Accessibility I tell my patient to use a gentle non-soap cleanser." 2021 Sep;35 (9):e546-e548. While annoyingly itchy, the rash does not cause any serious long-term side effects and is not contagious, unlike the diseases these vaccines protect against. COVID-19 vaccines reactions, type I hypersensitivity reactions (such as urticaria, angioedema, and anaphylaxis), . Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. Bin Rubaian NF, Almuhaidib SR, Aljarri SA, Alamri AS. The rash itself usually doesnt blister or bleed, but in many cases, the skin may peel. While it can spread all over the entire body, PR usually favors the trunk, says Christina Lam, an assistant professor of dermatology at Boston University School of Medicine and dermatologist at Boston Medical Center. Foods that have anti-inflammatory properties include: Foods that may increase inflammation include: There isnt any way to prevent pityriasis rosea. A virus may cause pityriasis rosea, but experts aren't sure. J Med Virol 2021; 93: 1850-1851. HHS Vulnerability Disclosure, Help J Eur Acad Dermatol Venereol. Disseminated erythematous-papulosquamous lesions, with right laterocervical herald patch (clinical aspect on admission). Abdullah L, Hasbani D, Kurban M, Abbas O. Pityriasis rosea after mRNA COVID-19 vaccination. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2022 Dec;9:127. doi: 10.1016/j.jdin.2022.03.018. Int J Dermatol. Would you like email updates of new search results? While you don't need to treat the rash, some patients ask for treatment to take care of the following. Clinical findings of pityriasis rosealike eruption in the patients. The most commonly inoculated vaccines include those against smallpox, followed by tuberculosis, poliomyelitis, influenza, and human papillomavirus virus (12, 13). Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. 2022 Sep-Oct;40(5):586-590. doi: 10.1016/j.clindermatol.2022.01.002. Authors Elina Khattab 1 , Eirini Christaki 2 , Constantinos Pitsios 1 Affiliations 1 Medical School, University of Cyprus, Nicosia, Cyprus. Among 171 laboratory-confirmed COVID-19 patients with cutaneous manifestations from the registry, the most commonly reported were morbilliform rash (22 percent), pernio-like acral lesions (18 percent), urticaria (16 percent), macular erythema (13 percent), vesicular eruption (11 percent), papulosquamous eruption (9.9 percent), and retiform Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. The Covid Symptom Study. About one to two weeks later, discolored circular or oval-shaped patches appear in groups near the herald patch. official website and that any information you provide is encrypted Your California Privacy Rights. (Unfortunately, I scratched my rash until it bled, so my hyperpigmentation may linger.). Pityriasis rosea commonly affects the skin on your trunk, arms or legs. From grooming sets to self-care gadgets, we've got them covered. (2021). This patch is the herald or mother patch. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Diagnostic and prognostic values of cutaneous manifestations in COVID-19. and transmitted securely. PMC J Formos Med Assoc. Adya KA, Inamadar AC, Albadri W. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. Marzano AV, Cassano N, Genovese G, Moltrasio C, Vena GA. Cutaneous manifestations in patients with COVID19: a preliminary review of an emerging issue. Int J Dermatol. The herald patch is the telltale sign that your rash could be PR, but there are other common (though not universal) symptoms as well. Epub 2021 Aug 7. Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. Department of Dermatology, Graduate School of Medicine, Kyusyu University, Japan. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk within days or weeks, says dermatologist Corey L. Hartman, founder of Skin Wellness Dermatology in Birmingham, Alabama. Disseminated erythematous-papulosquamous lesions, with right. J Am Acad Dermatol. Would you like email updates of new search results? Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. Br J Dermatol. To the best of our knowledge, only one case of ChAdOx1 nCoV-19 vaccine-induced PR-like eruption has been reported (2). 2005;124(6):12341240. Your rash looks infected (red, purple, gray or white skin; irritation and swelling). 2022 Aug 11;9(8):43. doi: 10.3390/medicines9080043. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. Br J Dermatol 2020; 183: 431442. government site. A virus may cause pityriasis rosea, but experts arent sure. J Am Acad Dermatol. Refined carbohydrates, such as sugar, pastries and white bread. In conclusion, we have described the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. Although the exact pathogenesis of PR is unknown, current evidence suggests that an inflammatory reaction due to a viral trigger may lead to the cutaneous manifestations. KL and KP collated resources. Involvement of the oral mucosa has also been reported in as many as 50% of all cases (11). Please enable it to take advantage of the complete set of features! Considering the actual epidemiological context, we performed a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay from nasal and pharyngeal swabs for coronavirus disease 2019 (COVID-19) to investigate the PR etiology. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. doi: 10.1111/ajd.13504. However, if you experience any symptoms, therapy can provide relief. COVID-19-associated pityriasis rosea in children: Case report and literature review. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. Clipboard, Search History, and several other advanced features are temporarily unavailable. PR also tends to occur in patients between the ages of 10 to 35 that are usually otherwise healthy, Lam says. Epub 2021 May 10. 2021 May;62(2):e333-e334. Pityriasis rosea is a common condition that causes discolored patches on your skin. -, Neoh CY, Tan AW, Mohamed K, et al. Pityriasis Rosea. The study said the appearance was similar to pityriasis rosea, a common skin condition. Histopathological findings of pityriasis rosealike eruption in patient 1. Parakeratosis with minimal acanthosis and spongiosis of the epidermis. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. An official website of the United States government. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. When to test for COVID-19 using real-time reverse transcriptase polymerase chain reaction: a systematic review. This site needs JavaScript to work properly. We do not endorse non-Cleveland Clinic products or services. For most people, it resolves without treatment. J Invest Dermatol. Pityriasis rosea Gibert is an erythematous-papulosquamous dermatosis that frequently occurs in young adults. Epub 2022 Jan 5. Clin Dermatol. Blood tests to check for causes of a rash that arent related to pityriasis rosea. (2006) 12:1. doi: 10.5070/D380D8301D, 11. Epub 2021 Aug 26. Some treatments can alleviate related symptoms, including itching. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). Also, topical medication with dermatocorticosteroids and emollients was associated. doi: 10.1111/jdv.17342. Federal government websites often end in .gov or .mil. Unauthorized use of these marks is strictly prohibited. (2019) 34:185764. Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosea-like eruptions: How to distinguish them? (a) Patient 1: Thin red to tan oval plaques with peripheral scale on the trunk. Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review. These conditions lasted 8.6 days on average. Cutaneous Eruptions in the Course of COVID-19 Among Geriatric Patients in a Nursing Home in Poland. Epub 2022 May 31. The .gov means its official. In some cases, central hyperpigmentation was identified. It should clear your body in six to eight weeks. Contact your healthcare provider as soon as you notice a rash. It was described as "clinically reminiscent" of pityriasis rosea by the authors, from the divisions of dermatology and venereology, pathology, intensive care, and the virology laboratory, of the Hpital Cochin, Paris. Pityriasis rosea doesnt usually affect people over the age of 60. NCI CPTC Antibody Characterization Program. One case of pityriasis rosea is reported in a patient infected with COVID-19, and the most commonly reported features are exanthomatous rash, urticaria, chickenpox like vesicles, petechiae, and acute hemorrhagic edema of infancy. For most people, it resolves without treatment. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same . Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. J Eur Acad Dermatol Venereol. 2022 by the American Academy of Dermatology, Inc. The typical distribution of the rash is on the trunk between the neck and the knees.". If you develop symptoms of pityriasis rosea while pregnant, contact your healthcare provider right away. A more recent letter in the International Journal of Dermatology reported a "unique case of pityriasis rosea following administration of mRNA COVID-19 vaccine." Figure 1. Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Int J Dermatol. Human herpesvirus-6,7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage, Herald patch of pityriasis rosea. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. (b) Patient 1: Closeup of a plaque. Bookshelf 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. doi: 10.1111/jdv.17316. ", Though there's no single-known cause, King says, "pityriasis rosea is associated with reactivation of herpesviruses 6 and 7 [HHV-6 and HHV-7, respectively], which cause the primary rash, roseola, in infants. "Like a lot of things in dermatology, unfortunately, we're not always sure what causes these rashes," says Lam. (2021) 85:4655. I also had to stop working out and hiking for about a week, as Alexiades is right excessive perspiration worsened the itch. What at-home treatments do you recommend? (2015) 2015:253154. doi: 10.1155/2015/253154, 14. 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. Herald patch in the right hypochondrium followed by typical oval-shaped secondary plaques, Pityriasis rosea lesions on the upper extremities, MeSH 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Bathe or shower in lukewarm water. Disclaimer. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. The patients/participants provided their written informed consent to participate in this study. JAAD Case Rep. (2018) 4:8001. Advertising on our site helps support our mission. 2021;35(9):e546e548. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine J Eur Acad Dermatol Venereol. official website and that any information you provide is encrypted official website and that any information you provide is encrypted National Library of Medicine Clipboard, Search History, and several other advanced features are temporarily unavailable. Bookshelf Those ensuing spots like the circle of dots that erupted on my back a day after the initial raised welt appeared typically resemble a Christmas tree-like formation. American Academy of Dermatology's National Library of Dermatologic Teaching Slides. doi: 10.12998/wjcc.v5.i6.203, 6. Epub 2022 Feb 9. "Other treatments including phototherapy or oral medications can be considered for extensive or persistent cases, [and] some small case studies support the use of oral antivirals like acyclovir or oral anti-inflammatory antibiotics erythromycin," King explains. (2016) 30:5445. These types cannot cause cold sores or genital herpes. J Med Virol. Pityriasis lichenoides has distinct acute and chronic forms, which are usually distinct . doi: 10.1111/dth.15040, 3. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. -, Broccolo F, Drago F, Careddu AM, et al. Some people who have had cosmetic fillers used to remove . The site is secure. We present two cases of COVID-19 vaccine-induced pityriasis rosea. The .gov means its official. Cutaneous manifestation has been reported in 0.2% of patients infected by COVID-19 in China, and 18 out of 88 patients from Italy. While unusual, one patient developed pityriasis rosea once a year for five years in a row.
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